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The journey began in the 1980s with research on Gila monster venom, culminating in the discovery of exendin-4, a stable, effective peptide for treating diabetes, demonstrating the progression from initial discovery to blockbuster diabetes medications

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For older adults, caution is advised due to the higher likelihood of underlying health conditions or medication use that might interact with the peptide

Recently, Just and collaborators showed that MOR is sequentially phosphorylated at S375, T370, T379, and T376 by DAMGO